2025.04.09.647859

Total: 1

#1 Mechanism of clinically relevant neurosecretory and metabolic impairment in Alzheimers and identification of engineered nanotherapy [PDF] [Copy] [Kimi] [REL]

Authors: Yutong Shang, Won Jin Cho, Seeya A Munj, Siddhartha G Jena, Suzan Arslanturk, Sushmita R Patil, Xin Qi, Bhanu P Jena

A central challenge in Alzheimers disease is understanding the mechanism of neuronal secretory dysfunction. By exploiting AI, we reveal how beta-amyloid disrupts key protein interactions within the neuronal secretory machinery. In a combinatorial strategy of reprogramming the neuronal secretory and metabolic components, we established a dual-target therapeutic framework that repairs synaptic and mitochondrial defects to counteract neurodegeneration in Alzheimers.

Subject: Neuroscience

Publish: 2025-04-10