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Referring MLLMs extend conventional multimodal large language models by allowing them to receive referring visual prompts and generate responses tailored to the indicated regions. However, these models often suffer from suboptimal performance due to incorrect responses tailored to misleading areas adjacent to or similar to the target region. This work introduces CPCF, a novel framework to address this issue and achieve superior results. CPCF contrasts outputs generated from the indicated visual prompt with those from contrastive prompts sampled from misleading regions, effectively suppressing the influence of erroneous information outside the target region on response generation. To further enhance the effectiveness and efficiency of our framework, several novel designs are proposed, including a prompt extraction network to automatically identify suitable contrastive prompts, a self-training method that leverages unlabeled data to improve training quality, and a distillation approach to reduce the additional computational overhead associated with contrastive decoding. Incorporating these novel designs, CPCF achieves state-of-the-art performance, as demonstrated by extensive experiments across multiple benchmarks. Project page: https://lanyunzhu.site/CPCF/