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Machine learning approaches to relation extraction are typically supervised and require expensive labeled data. To break the bottleneck of labeled data, a promising approach is to exploit easily obtained indirect supervision knowledge – which we usually refer to as distant supervision (DS). However, traditional DS methods mostly only exploit one specific kind of indirect supervision knowledge – the relations/facts in a given knowledge base, thus often suffer from the problem of lack of supervision. In this paper, we propose a global distant supervision model for relation extraction, which can: 1) compensate the lack of supervision with a wide variety of indirect supervision knowledge; and 2) reduce the uncertainty in DS by performing joint inference across relation instances. Experimental results show that, by exploiting the consistency between relation labels, the consistency between relations and arguments, and the consistency between neighbor instances using Markov logic, our method significantly outperforms traditional DS approaches.