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Sum-product networks (SPNs) are a class of probabilistic graphical models that allow tractable marginal inference. However, the maximum a posteriori (MAP) inference in SPNs is NP-hard. We investigate MAP inference in SPNs from both theoretical and algorithmic perspectives. For the theoretical part, we reduce general MAP inference to its special case without evidence and hidden variables; we also show that it is NP-hard to approximate the MAP problem to 2nε for fixed 0 ≤ ε < 1, where n is the input size. For the algorithmic part, we first present an exact MAP solver that runs reasonably fast and could handle SPNs with up to 1k variables and 150k arcs in our experiments. We then present a new approximate MAP solver with a good balance between speed and accuracy, and our comprehensive experiments on real-world datasets show that it has better overall performance than existing approximate solvers.