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The widespread existence of wrongly labeled instances is a challenge to distantly supervised relation extraction. Most of the previous works are trained in a bag-level setting to alleviate such noise. However, sentence-level training better utilizes the information than bag-level training, as long as combined with effective noise alleviation. In this work, we propose a novel Transitive Instance Weighting mechanism integrated with the self-distilled BERT backbone, utilizing information in the intermediate outputs to generate dynamic instance weights for denoised sentence-level training. By down-weighting wrongly labeled instances and discounting the weights of easy-to-fit ones, our method can effectively tackle wrongly labeled instances and prevent overfitting. Experiments on both held-out and manual datasets indicate that our method achieves state-of-the-art performance and consistent improvements over the baselines.