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The few-shot relation extraction (FSRE) aims at enhancing the model’s generalization to new relations with very few labeled instances (support instances). Most existing studies use prototype networks (ProtoNets) for FSRE and assume that the support set, adapting the model to new relations, only contains accurately labeled instances. However, this assumption is usually unrealistic, as even carefully-annotated datasets often contain mislabeled instances. Thus, it is essential to enhance the robustness of FSRE models to noisy labels in support set, but this issue remains unexplored. In this paper, we first conduct a preliminary study, revealing the high sensitivity of ProtoNets to such noisy labels. Meanwhile, we discover that fully leveraging mislabeled support instances is crucial for enhancing the model’s robustness. To do this, we propose a self-denoising model for FSRE, which can automatically correct noisy labels of support instances. Specifically, our model comprises two core components: 1) a label correction module (LCM), used to correct mislabeled support instances based on the distances between them in the embedding space, and 2) a relation classification module (RCM), designed to achieve more robust relation prediction using the corrected labels generated by the LCM. Moreover, we propose a feedback-based training strategy, which focuses on training LCM and RCM to synergistically handle noisy labels in support set. Experimental results on two public datasets show the effectiveness and robustness of our model. Notably, even in scenarios without noisy labels, our model significantly outperforms all competitive baselines.