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State-of-the-art machine-learned controllers for autonomous systems demonstrate unbeatable performance in scenarios known from training. However, in evolving environments---changing weather or unexpected anomalies---, safety and interpretability remain the greatest challenges for autonomous systems to be reliable and are the urgent scientific challenges. Existing machine-learning approaches focus on recovering lost performance but leave the system open to potential safety violations. Formal methods address this problem by rigorously analysing a smaller representation of the system but they rarely prioritize performance of the controller. We propose to combine insights from formal verification and runtime monitoring with interpretable machine-learning design for guaranteeing reliability of autonomous systems.