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Recent research on predicting the binding affinity between drug molecules and proteins use representations learned, through unsupervised learning techniques, from large databases of molecule SMILES and protein sequences. While these representations have significantly enhanced the predictions, they are usually based on a limited set of modalities, and they do not exploit available knowledge about existing relations among molecules and proteins. Our study reveals that enhanced representations, derived from multimodal knowledge graphs describing relations among molecules and proteins, lead to state-of-the-art results in well-established benchmarks (first place in the leaderboard for Therapeutics Data Commons benchmark ``Drug-Target Interaction Domain Generalization Benchmark", with an improvement of 8 points with respect to previous best result). Moreover, our results significantly surpass those achieved in standard benchmarks by using conventional pre-trained representations that rely only on sequence or SMILES data. We release our multimodal knowledge graphs, integrating data from seven public data sources, and which contain over 30 million triples. Pretrained models from our proposed graphs and benchmark task source code are also released.