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This paper introduces a novel approach to Model-Based Diagnosis (MBD) for hybrid technical systems. Unlike existing approaches which normally rely on qualitative diagnosis models expressed in logic, our approach applies a learned quantitative model that is used to derive residuals. Based on these residuals a diagnosis model is generated and used for a root cause identification. The new solution has several advantages such as the easy integration of new machine learning algorithms into MBD, a seamless integration of qualitative models, and a significant speed-up of the diagnosis runtime. The paper at hand formally defines the new approach, outlines its advantages and drawbacks, and presents an evaluation with real-world use cases.