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Diffusion models have proven to be highly effective in image and video generation; however, they encounter challenges in the correct composition of objects when generating images of varying sizes due to single-scale training data. Adapting large pre-trained diffusion models to higher resolution demands substantial computational and optimization resources, yet achieving generation capabilities comparable to low-resolution models remains challenging. This paper proposes a novel self-cascade diffusion model that leverages the knowledge gained from a well-trained low-resolution image/video generation model, enabling rapid adaptation to higher-resolution generation. Building on this, we employ the pivot replacement strategy to facilitate a tuning-free version by progressively leveraging reliable semantic guidance derived from the low-resolution model. We further propose to integrate a sequence of learnable multi-scale upsampler modules for a tuning version capable of efficiently learning structural details at a new scale from a small amount of newly acquired high-resolution training data. Compared to full fine-tuning, our approach achieves a 5× training speed-up and requires only 0.002M tuning parameters. Extensive experiments demonstrate that our approach can quickly adapt to higher-resolution image and video synthesis by fine-tuning for just 10k steps, with virtually no additional inference time.