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Local search is a popular technique to solve combinatorial optimization problems efficiently. To escape local minima one generally uses metaheuristics or try to design large neighborhoods around the current best solution. A somewhat more black box approach consists in using an optimization solver to explore a large neighborhood. This is the large-neighborhood search (LNS) idea that we reuse in this work. We introduce a generic neighborhood exploration algorithm based on restricted decision diagrams (DD) constructed from the current best solution. We experiment DD-LNS on two sequencing problems: the traveling salesman problem with time windows (TSPTW) and a production planning problem (DLSP). Despite its simplicity, DD-LNS is competitive with the state-of-the-art MIP approach on DLSP. It is able to improve the best known solutions of some standard instances for TSPTW and even to prove the optimality of quite a few other instances.