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In this paper, we propose a unified layout planning and image generation model, PlanGen, which can pre-plan spatial layout conditions before generating images as shown in Figure 1. Unlike previous diffusion-based models that treat layout planning and layout-to-image as two separate models, PlanGen jointly models the two tasks into one autoregressive transformer using only next-token prediction. PlanGen integrates layout conditions into the model as context without requiring specialized encoding of local captions and bounding box coordinates, which provides significant advantages over the previous embed-and-pool operations on layout conditions, particularly when dealing with complex layouts. Unified prompting allows PlanGen to perform multitasking training related to layout, including layout planning, layout-to-image generation, image layout understanding, etc. In addition, PlanGen can be seamlessly expanded to layout-guided image manipulation thanks to the well-designed modeling, with teacher-forcing content manipulation policy and negative layout guidance. Extensive experiments verify the effectiveness of our PlanGen in multiple layout-related tasks, showing its great potential.