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RGB-Thermal (RGBT) multispectral vision is essential for robust perception in complex environments. Most RGBT tasks follow a case-by-case research paradigm, relying on manually customized models to learn task-oriented representations. Nevertheless, this paradigm is inherently constrained by artificial inductive bias, modality bias, and data bottleneck. To address these limitations, we make the initial attempt to build a Generalized RGBT MultiSpectral foundation model (M-SpecGene), which aims to learn modality-invariant representations from large-scale broad data in a self-supervised manner. M-SpecGene provides new insights into multispectral fusion and integrates prior case-by-case studies into a unified paradigm. Considering the unique characteristic of information imbalance in RGBT data, we introduce the Cross-Modality Structural Sparsity (CMSS) metric to quantify the information density across two modalities. Then we develop the GMM-CMSS progressive masking strategy to facilitate a flexible, easy-to-hard, and object-centric pre-training process. Comprehensive experiments validate M-SpecGene's generalizability across eleven datasets for four RGBT downstream tasks.