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Speech research is remarkable in so many ways – in its essential human-centeredness, the rich interconnections between the science and technology, and its wide-ranging impact that is both fundamental and applied. Crucial advances in speech science research catalyze and leverage technological advances across the machine intelligence ecosystem, from sensing and imaging to signal processing and machine learning. Likewise, creation of speech-centric societal applications benefits from an understanding of how humans produce, process and use speech in communication. In these complementary endeavors, two intertwined lines of inquiry endure: illuminating the rich information tapestry and inherent variability in speech and creating trustworthy speech technologies.