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It is indispensable to establish an objective test methodology for noise-reduced speech. This paper proposes a new methodology which estimates word intelligibility of the noise-reduced speech from PESQ MOS (subjective MOS estimated by the PESQ). To evaluate the effectiveness of the proposed methodology, a word intelligibility test of the noise-reduced speech was performed by using four noise reduction algorithms and word lists which take word difficulty into account, and then the word intelligibility was estimated by the proposed methodology. The results confirmed that the word intelligibility can be estimated well from the PESQ MOS without distinguishing the noise reduction algorithms and the noise types.