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In the realm of audio-language pre-training (ALP), the challenge of achieving cross-modal alignment is significant. Moreover, the integration of audio inputs with diverse distributions and task variations poses challenges in developing generic audio-language models. In this study, we present MINT, a novel ALP framework boosting audio-language models through multi-target pre-training and instruction tuning. MINT leverages the strength of frozen pre-trained audio encoders and large language models (LLM) to improve audio-language pretraining, enabling effective transferablility to both audio-text understanding and generation tasks. To address the modality gap, we introduce Bridge-Net, a trainable module that enhances cross-modality alignment and the model’s ability to follow in- structions for a variety of audio-text tasks. Bridge-Net is pivotal within MINT, initially enhancing audio-language representation learning through a multi-target pre-training approach. Subsequently, Bridge-Net further boosts audio-to-language generative learning by integrating a frozen language model with instruction tuning. This integration empowers MINT to extract features in a flexible and effective manner, specifically tailored to the provided instructions for diverse tasks. Experimental results demonstrate that MINT attains superior performance across various audio-language understanding and generation tasks, highlighting its robust generalization capabilities even in zero-shot scenarios.